Global Prime Editing Technology Market

Prime Editing Technology Market Insights

Genome editing or most profoundly called gene editing is a set of advanced tools and technologies that are involved in the alteration of a particular DNA sequence. Genome editing lets the scientists indulge in adding, removing, or altering a particular gene/ genetic material at a précised location on the genome. The market has witnessed various types of approaches that fall under the umbrella of genome editing across the globe. These are Cas9 (CRISPR-associated protein 9), ZFNs (zinc-finger nucleases), CRISPR (clustered regularly interspaced short palindromic repeats), TALENs (transcription activator-like effector nucleases), and Antisense. A new addition to the list of technologies is the prime editing technology which was recently proposed i.e. in the early months of 2019. Famously called “search and replace” technology, prime editing is a genetic or DNA strand editing technology that can do gene base manipulation using the prime gene part of the DNA. Insertion, deletion, and base swapping are the major roles of this technology.

The fusion protein is used in the process which consists of Cas9 endonuclease i.e. a catalyst that is chemically fused with reverse transcriptase enzyme.Furthermore, a prime editing guide RNA or famously called pegRNAis used to precisely identify the target site and alter the new geneor the genetic information by replacing the targeted DNA nucleotides. Prime editing or also termed as “genetic word processor”accurately selects the existing genetic code of the targeted DNA and replaces it with the desired genetic code. Precise editing and superior target flexibility are the main reasons for this technology to augment the gene-editing industry. Considering these advantages, many manufacturers have announced organic growth strategies i.e. collaboration, partnership, and mergers to launch prime editing technology in the market. Some of these companies include Beam Therapeutics Inc., CRISPR Therapeutics, and Synthego Corporation.

Increasing demand for targeted gene manipulation in biomedical and agricultural research will propagate the growth of the prime editing technology market. Moreover, the rising prevalence of genetic-based disorders and the rising number ofsickle cell anaemia cases will help the prime editing technology market grow gradually. Besides, the rapidly decreasing cost of DNA sequencing services will open doors of growth opportunities for this market. Also increasing government funds for genetic innovation-based research, rising demand for personalized drugs and novel drugs, increasing research & developmental activities for cancer and genetic-based disorders, increasing application of gene editing in agricultural research for novel seed/ grain study, and rising pharmaceutical R&D expenditure will help the market grow from 2021 to 2026. However, the lack of government norms or regulations for this technology (as it is in its nascent stage) will pose a challenge for the prime editing technology market. Because of its feature of offering minimal errors in gene replacement during the editing process, this technologygrows rapidly in the market from 2021 to 2026. The major services that will be offered using this technology are cell line engineering, regulation of the genome, gene editing, and gene-modified cell therapy.

Prime Editing Technology Market: By Services

Based on the type of services, the market can be split into cell line engineering, regulation of the genome, gene editing, and gene-modified cell therapy. The gene-editing segment will be the largest segment owing to the rising demand for prime editing technology in targeted drug discovery, personalized drug, and genome-based disease study.

Prime Editing Technology Market: By Application

As per the applications, the market for prime editing technology can be split into biomedical research, agricultural research, and other application.Biomedical research will hold the lion’s share in the market, but the agricultural research segment will grow with a higher value of CAGR from 2021 to 2026. The rising prevalence of genetic-based disorders and the rising number ofsickle cell anaemia in developing regions will promote the adoption of prime editing technology in the biomedical research field.

Prime Editing Technology Market: By End-User

Based on the potential customers of this field, the market can be split into, academic institutions, biotechnology & pharma companies, independent laboratories, and contract research organizations (CROs). Owing to the newness of this technology, the market for contract research organizations (CROs) will be seen to be dominating the market during the forecast period.

Prime Editing Technology Market: By Region

As per the geographical analysis, the market can be classified into North America (the US, Canada, and Mexico), Asia Pacific (India, China, Japan, Malaysia, Singapore, and Rest of Asia Pacific), Europe (Germany, United Kingdom, Italy, France, Spain, Netherlands, and Rest of Europe), Middle East & Africa and Central South America.Amongst these regions, the North American region will be the dominant regional segment in the market. This is attributed to the high presence of genetic diseases in the population of the US and rising awareness amongst American scientists on the advantages of prime technology. After North America, Europe will be the second-largest growing segment for prime editing technology. The genetic disorder namely Tay Sachs is mostly found in the Jews residents residing in Europe. This technology can be a boom for understanding and treating this disorder. Hence, besides the US, Europe is the next big market for this technology. Asia is reaching the top list of being home to the huge patient population suffering from Cystic Fibrosis and Hemophilia. This opens doors of opportunities for this region to grow rapidly in the market during the forecast period.

Prime Editing Technology Market Shareand Competitor Analysis

Beam Therapeutics Inc., Inscripta Inc., Precision BioSciences, Sangamo Therapeutics, Inc., Horizon Discovery Ltd., CRISPR Therapeutics., GenScript, Intellia Therapeutics Inc., and Synthego Corporation are the potential players to enter the prime editing technology market.(These are one of the top biotechnology companies)

Please note: This is not an exhaustive list of companies profiled in the report.

In October 2019, one of the top precision genetic-based medicines, Beam Therapeutics, Inc., entered into an exclusive collaborative deal with Prime Medicine for launching prime technology.